"Sandwich" Diimine-Copper Catalysts for C-H Functionalization by Carbene Insertion

被引：19

作者：

Klimovica, Kristine ^{[1
]}

Heidlas, Julius X. ^{[1
]}

Romero, Irvin ^{[1
]}

Le, Thanh V. ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, 3585 Cullen Blvd, Houston, TX 77004 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 31期

关键词：

C-H Activation; Carbenes; Copper; Diazo Compounds; Diimines; BOND FUNCTIONALIZATION; C(SP(3))-H; DONOR; POLYETHYLENE; ACTIVATION; CHALLENGES; COMPLEXES; ETHYLENE; ALKANES;

D O I：

10.1002/anie.202200334

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here "sandwich" diimine-copper(I) catalysts for C(sp(3))-H bond functionalization. Reactions of alkanes and ethers with trimethylsilyldiazomethane, ethyl diazoacetate, and trifluoromethyl-diazomethane have been demonstrated. We also report C(sp(3))-H bond methylation, benzylation, and diphenylmethylation by diazomethane, aryldiazomethanes, and diphenyldiazomethane. These reactions are rare examples of base-metal catalyzed, intermolecular C(sp(3))-H functionalizations by employing unactivated diazo compounds. Electrophilicity and unique steric environment of "sandwich"-copper catalysts are likely reasons for their catalytic efficiency.

引用

页数：6

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