Levofloxacin in veterinary medicine: a literature review

被引:31
作者
Sitovs, Andrejs [1 ]
Sartini, Irene [2 ]
Giorgi, Mario [3 ]
机构
[1] Riga Stradins Univ, Dept Pharmacol, Dzirciema Str 16, LV-1007 Riga, Latvia
[2] Univ Sassari, Dept Vet Med, Sassari, Italy
[3] Univ Pisa, Dept Vet Sci, Pisa, Italy
关键词
levofloxacin; MIC; pharmacokinetics; review; tissue residue; RESISTANT STAPHYLOCOCCUS-PSEUDINTERMEDIUS; URINARY-TRACT-INFECTIONS; PLASMA-PROTEIN BINDING; ESCHERICHIA-COLI; ANTIMICROBIAL SUSCEPTIBILITY; IN-VITRO; PSEUDOMONAS-AERUGINOSA; ANTIBIOTIC-RESISTANCE; DOSAGE REGIMEN; MOLECULAR CHARACTERIZATION;
D O I
10.1016/j.rvsc.2021.04.031
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A potent third-generation antimicrobial fluoroquinolone drug, levofloxacin was introduced into human clinical practice in 1993. Levofloxacin is also used in veterinary medicine, however its use is limited: it is completely banned for veterinary use in the EU, and used extralabel in only companion animals in the USA. Since its introduction to clinical practice, many studies have been published on levofloxacin in animal species, including pharmacokinetic studies, tissue drug depletion, efficacy, and animal microbial isolate susceptibility to levofloxacin. This literature overview highlights the most clinically relevant and scientifically important levofloxacin studies linked to the field of veterinary medicine.
引用
收藏
页码:111 / 126
页数:16
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