In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus

被引：79

作者：

Carriel-Gomes, Marcia Cristina

Kratz, Jadel Muller

Barracco, Margherita Anna

Bachere, Evelyne

Barardi, Celia Regina Monte

Simoes, Claudia Maria Oliveira

机构：

[1] Univ Fed Santa Catarina, Lab Virol Aplicada, Dept Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Lab Imunol Aplicada Aquicultura, Dept Biol Celular Embriol & Genet, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Microbiol & Parasitol, Lab Virol Aplicada, BR-88040900 Florianopolis, SC, Brazil

[4] Univ Montpellier 2, CNRS, Montpellier, France

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2007年 / 102卷 / 04期

关键词：

antimicrobial peptides; antiviral activity; herpesvirus; adenovirus; rotavirus;

D O I：

10.1590/S0074-02762007005000028

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.

引用

页码：469 / 472

页数：4

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