Synthesis and Properties of Temperature-Sensitive Hydrogel Based on Hydroxyethyl Cellulose

被引：36

作者：

Peng, Zhiyuan ^{[1
]}

Chen, Fangeng ^{[1
]}

机构：

[1] S China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS | 2010年 / 59卷 / 06期

关键词：

2; 4-toluene diisocyanate; hydrogel; hydroxyethyl cellulose; monoblock; N-isopropylacrylamide; temperature-sensitive; N-ISOPROPYLACRYLAMIDE; CONTROLLED-RELEASE; CROSS-LINKING; POLYMERIZATION; DERIVATIVES;

D O I：

10.1080/00914030903538637

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydrogels were prepared from modified hydroxyethyl cellulose by copolymerization with N-isopropylacrylamide. The equilibrium swelling ratio of hydrogel was measured in buffer solution with pH 7.0 from 25.0 to 45.0 degrees C and the data obtained showed that hydrogels exhibited temperature sensitivity. The results of DSC analysis revealed that the low critical solution temperature (LCST) of hydrogels was enhanced by the introduction of hydroxyethyl cellulose. SEM images suggested that the cross-section of freeze-dried hydrogels was porous. The data of adsorption and release experiments for two model drugs suggest that the controlled drug release can be achieved.

引用

页码：450 / 461

页数：12

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