An enantioselective synthesis of the C1-C9 segment of antitumor macrolide peloruside A

被引：29

作者：

Ghosh, AK ^{[1
]}

Kim, JH ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(03)00744-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled synthesis of the C-1-C-9 segment of the marine natural product peloruside A is described. The key steps involve Sharpless's catalytic asymmetric dihydroxylation reaction, a chelation-controlled reduction of chiral beta-alkoxy ketones to elaborate the syn-1,3-diol functionality and a ring-closing olefin metathesis of a homoallylic alcohol-derived acrylate ester to form an alpha,beta-unsaturated delta-lactone. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3967 / 3969

页数：3

共 23 条

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