Effect of hyperglycemia and insulin in acute coronary syndromes

被引：20
作者：
Dandona, Paresh
Chaudhuri, Ajay
Ghanim, Husarn
Mohanty, Priya
机构：
[1] SUNY Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14260 USA
[2] Kaleida Hlth, Buffalo, NY USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2007年 / 99卷 / 11A期
关键词：
D O I：
10.1016/j.amjcard.2007.04.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previously published data clearly demonstrate that hyperglycemia worsens morbidity and mortality in patients in intensive care, those with acute myocardial infarction and stroke, and those undergoing coronary artery bypass grafting. The control of hyperglycemia with insulin infusion improves clinical outcomes in these patients. In this article, we discuss data that demonstrate a proinflammatory effect of glucose and free fatty acids and an anti-inflammatory effect of insulin. We also provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusion in hospitalized patients. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：12H / 18H
页数：7
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