Rhodium(III)-Catalyzed C-H Activation / Alkylation of Diazabicyclic Olefins with Aryl Ketones: Facile Synthesis of Functionalized Cyclopentenes

被引：4
作者：
Santhini, P. V. [1 ,2 ]
Gopalan, Greeshma [1 ,2 ]
Smrithy, A. S. [1 ]
Radhakrishnan, K. V. [1 ,2 ]
机构：
[1] Natl Inst Interdisciplinary Sci & Technol CSIR, Organ Chem Sect, Trivandrum 695019, Kerala, India
[2] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India
来源：
SYNLETT | 2018年 / 29卷 / 15期
关键词：
C-H activation; aryl ketones; diazabicyclic olefins; cyclopentenes; stereoselectivity; MESO-BICYCLIC HYDRAZINES; PALLADIUM-CATALYZED REACTION; ONE-POT STRATEGY; BOND ACTIVATION; AZABICYCLIC OLEFINS; ALKENES; ACCESS; DESYMMETRIZATION; REAGENTS; HALIDES;
D O I：
10.1055/s-0037-1610654
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthesis of biologically important trans -functionalized cyclopentenes by a mild Rh(III)-catalyzed alkylation of strained diazabicyclic olefins with aryl ketones in the presence of ammonium acetate has been developed. The reaction proceeds through C-H bond activation of the aryl ketone groups by transforming them in to an autocleavable directing group, such as in situ-formed imine.
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页码：2023 / 2026
页数：4
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