Direct sp3 C-H bond activation adjacent to nitrogen in heterocycles

被引:695
作者
Campos, Kevin R. [1 ]
机构
[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA
关键词
D O I
10.1039/b607547a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Activation of sp(3) C - H bonds adjacent to nitrogen in heterocycles is an attractive transformation that is emerging as a practical method in organic synthesis. This tutorial review aims to summarize the key examples of direct functionalization of nitrogen-containing heterocycles via metalmediated and metal-catalyzed processes, which is meant to serve as a foundation for future investigations into this rapidly developing area of research. The review covers functionalization of N-heterocycles via alpha-lithiation with alkyllithium/diamine complexes, alpha-amino radical formation, metal-catalyzed direct C - H activation, C - H oxidations and oxidative couplings, and metalcatalyzed carbene insertions.
引用
收藏
页码:1069 / 1084
页数:16
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