New isomalabaricane analogues from the sponge Rhabdastrella providentiae and their cytotoxic activities

被引：16

作者：

Phan Van Kiem ^{[1
,2
]}

Duong Thi Dung ^{[1
,2
]}

Pham Hai Yen ^{[1
]}

Nguyen Xuan Nhiem ^{[1
]}

Tran Hong Quang ^{[1
]}

Bui Huu Tai ^{[1
,2
]}

Chau Van Minh ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2018年 / 26卷

关键词：

Rhabdastrella providentiae; Rhabdastrellin; Isomalabaricane analog; Marine sponge; A-F; GLOBOSTELLATA; TRITERPENES; DERIVATIVES;

D O I：

10.1016/j.phytol.2018.06.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new isomalabaricane analogues, named rhabdastrellins G - K (1-5), and three known compounds including jaspolide C (6), globostelletin C (7), and globostelletin D (8) were isolated from the sponge Rhabdastrella providentiae collected in the Eastern Sea of Vietnam. Their chemical structures were determined by HR-ESI-MS, NMR spectroscopy, experimental and calculated circular dichroism spectra. The isolated secondary metabolites were evaluated for their cytotoxicity toward HepG2, LU-1, MCF-7, HL-60, and SK-Mel2 human cancer cell lines. New isomalabaricane analogues 1-3 exhibited significant cytotoxicity with IC50 values ranging from 11.2 +/- 1.4 to 84.8 +/- 6.7 mu M. Interestingly, the 20(22)Z stereoisomer (2) exhibited dramatic increase of cytotoxic activity in comparison with 20(22)E isomer (1).

引用

页码：199 / 204

页数：6

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