Aldosterone and Mineralocorticoid Receptors in the Cardiovascular System

被引:68
作者
Funder, John W. [1 ]
机构
[1] Monash Med Ctr, Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia
关键词
HEART-FAILURE; BLOOD-PRESSURE; BINDING-SITES; EPLERENONE; RATS; HYPERTENSION; ATHEROSCLEROSIS; CORTICOSTERONE; SPECIFICITY; ANTAGONISM;
D O I
10.1016/j.pcad.2009.12.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aldosterone is currently thought to exert its physiologic effects by activating epithelial mineralocorticoid receptors, and its pathologic effects on the cardiovascular system via mineralocorticoid receptors in the heart and blood vessels. Recent studies have extended this understanding to include a reevaluation of the roles of aldosterone and mineralocorticoid receptor activation in blood pressure control; the rapid, nongenomic effects of aldosterone; the role of cortisol as a mineralocorticoid receptor agonist under conditions of redox change/tissue damage/reactive oxygen species generation; the growing consensus that primary aldosteronism accounts for approximately 10% of all essential hypertension; recent new insights into the cardioprotective role of spironolactone; and the development of third- and fourth-generation mineralocorticoid receptor antagonists for use in cardiovascular and other inflammatory disease. These findings on aldosterone action and mineralocorticoid receptor blockade are analyzed in the context of the prevention and treatment of cardiovascular disease. © 2010.
引用
收藏
页码:393 / 400
页数:8
相关论文
共 43 条
[1]   Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea [J].
Calhoun, DA ;
Nishizaka, MK ;
Zaman, MA ;
Harding, SM .
CHEST, 2004, 125 (01) :112-117
[2]  
CONN JW, 1955, J LAB CLIN MED, V45, P3
[4]   EVIDENCE FOR SECRETION OF AN ALDOSTERONE - STIMULATING HORMONE BY KIDNEY [J].
DAVIS, JO ;
AYERS, CR ;
HOLMAN, JE ;
BAHN, RC ;
CARPENTER, CC .
JOURNAL OF CLINICAL INVESTIGATION, 1961, 40 (04) :684-&
[5]   ROLE OF RENIN-ANGIOTENSIN SYSTEM IN CONTROL OF ALDOSTERONE SECRETION [J].
DAVIS, JO ;
TITUS, EO ;
SPIEGEL, HE ;
CARPENTER, CCJ ;
AYERS, CR ;
HARTROFT, PM .
JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (02) :378-&
[6]   LOCALIZATION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR [J].
EDWARDS, CRW ;
BURT, D ;
MCINTYRE, MA ;
DEKLOET, ER ;
STEWART, PM ;
BRETT, L ;
SUTANTO, WS ;
MONDER, C .
LANCET, 1988, 2 (8618) :986-989
[7]  
Epstein M, 1998, J AM SOC NEPHROL, V9, pA1640
[8]  
EPSTEIN M, 2002, AM J HYPERTENS A, V24, P15
[9]   Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor [J].
Fjeld, CC ;
Birdsong, WT ;
Goodman, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9202-9207
[10]   Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: In vivo binding studies [J].
Funder, J ;
Myles, K .
ENDOCRINOLOGY, 1996, 137 (12) :5264-5268