Role of new Immunophenotypic Markers on Prognostic and Overall Survival of Acute Myeloid Leukemia: a Systematic Review and Meta-Analysis

被引：19

作者：

Costa, A. F. O. ^{[1
]}

Menezes, D. L. ^{[1
]}

Pinheiro, L. H. S. ^{[1
]}

Sandes, A. F. ^{[2
]}

Nunes, M. A. P. ^{[3
]}

Lyra Junior, D. P. ^{[1
]}

Schimieguel, D. M. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Hematol Lab, Dept Pharm, Aracaju, Sergipe, Brazil

[2] Fleury Grp, Hematol Div, Sao Paulo, SP, Brazil

[3] Univ Fed Sergipe, Dept Med, Aracaju, Sergipe, Brazil

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

MINIMAL RESIDUAL DISEASE; FLOW-CYTOMETRY; EXPRESSION; DIAGNOSIS; BIOMARKER; IMPACT; CD82; AML;

D O I：

10.1038/s41598-017-00816-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Despite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall survival (OS) rate of AML patients. Therefore, we conducted a systematic review and meta-analysis of PubMed, Scopus, Science Direct, Web of Science, and the Cochrane Library (using PRISMA guidelines). We analyzed 11 studies and 13 antigens, detected through the immunophenotyping of 639 patients. From them, twelve exhibited a negative impact with AML prognosis. The meta-analysis demonstrated a high expression of AML markers, which have been associated with a decrease in survival over 10 months (RR 2.55; IC 95%; 1.49-4.37) and over 20 months (RR 2.46; IC 95%; 1.75-3.45). Knowing that the expression of immunophenotypic markers, which are not used on a routine basis, might be able to influence disease behavior, looks promising. However, they have been associated with a poor prognosis as well as a decrease in survival. This may allow for different chemotherapeutical protocols, including future studies for new therapeutic targets.

引用

页数：11

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