Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons

被引：25

作者：

Chen, SC

Wu, FS ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Physiol, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan

来源：

BRAIN RESEARCH | 2004年 / 1027卷 / 1-2期

关键词：

pregnenolone sulfate; capsaicin receptor; dorsal root ganglion neurons; whole-cell recording; neuromodulation; nociception;

D O I：

10.1016/j.brainres.2004.08.053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of pregnenolone sulfate (PS) on the capsaicin receptor-mediated current was studied in acutely dissociated rat dorsal root ganglion neurons using the whole-cell voltage-clamp technique. PS acted extracellularly to inhibit the capsaicin-induced current in a not competitive but concentration-dependent manner, with an EC50 of 13 muM and a maximal inhibition of 65%. Furthermore, antagonism of the capsaicin response by PS is neither voltage- nor agonist-dependent, indicating that PS did not act as an open-channel blocker. The inhibitory action of PS on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：196 / 200

页数：5

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