Synthesis of enterolactone and enterodiol precursors as potential inhibitors of human estrogen synthetase (aromatase)

被引：30
|
作者：
Mäkelä, TH [1 ]
Wähälä, KT [1 ]
Hase, TA [1 ]
机构：
[1] Univ Helsinki, Dept Chem, Organ Chem Lab, FIN-00014 Helsinki, Finland
来源：
STEROIDS | 2000年 / 65卷 / 08期
关键词：
lignan; lactones; Michael reactions; synthesis;
D O I：
10.1016/S0039-128X(00)00104-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of variably substituted derivatives of lignan lactones and diols were prepared using tandem conjugate addition reaction as a key step. These theoretical precursors of the mammalian lignans enterolactone 1 and enterodiol 3 are moderate or weak inhibitors of human aromatase activity. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：437 / 441
页数：5
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