Exogenous nucleosides are required for the morphogenesis of the human filarial parasite Brugia malayi

被引：2

作者：

Rajan, TV ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Pathol, Farmington, CT 06032 USA

来源：

JOURNAL OF PARASITOLOGY | 2004年 / 90卷 / 05期

关键词：

D O I：

10.1645/GE-308R

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a human disease known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. The parasites enter the human host from the mosquito as L3 or infective larvae and subsequently differentiate through 2 molts. In this communication, I report that B. malayi and B. pahangi depend on an exogenous source of at least 1 purine and 1 pyrimidine nucleoside to complete the L3 to L4 molt. The requirement for exogenous nucleosides opens the door for possible chemotherapeutic intervention.

引用

页码：1184 / 1185

页数：2

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