The Suzuki, the Heck, and the Stille reaction -: three versatile methods for the introduction of new C-C bonds on solid support

被引：91

作者：

Franzén, R ^{[1
]}

机构：

[1] Univ Helsinki, Dept Pharm, Dept Pharmaceut Chem, FIN-00014 Helsinki, Finland

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2000年 / 78卷 / 07期

关键词：

metal-catalyzed coupling reactions; carbon-carbon bonds; solid phase synthesis; combinatorial chemistry; drug discovery;

D O I：

10.1139/cjc-78-7-957

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-catalyzed coupling reactions are very efficient and reliable methods for the introduction of new carbon-carbon bonds onto molecules attached to a solid support. This review summarizes recent advances in utilizing the three most used methods, the Suzuki reaction, the Heck reaction, and the Stille reaction, in the field of solid phase organic synthesis resulting in small organic molecule libraries.

引用

页码：957 / 962

页数：6

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