PET imaging for suspected residual tumour or thoracic recurrence of non-small cell lung cancer after pneumonectomy

被引:12
作者
Roberts, KB
Mac Manus, MP
Hicks, RJ
Rischin, D
Wirth, A
Wright, GM
Ball, DL
机构
[1] Peter MacCallum Canc Inst, Dept Radiat Oncol, Melbourne, Vic 3000, Australia
[2] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA
[3] Peter MacCallum Canc Inst, Dept Mol Imaging, Melbourne, Vic 3000, Australia
[4] Peter MacCallum Canc Inst, Dept Med Oncol, Melbourne, Vic 3000, Australia
[5] Peter MacCallum Canc Inst, Dept Surg Oncol, Melbourne, Vic 3000, Australia
[6] Univ Melbourne, Peter MacCallum Canc Inst, Melbourne, Vic 3000, Australia
关键词
non-small cell lung cancer; positron emission tomography; pneumonectomy; radiotherapy; metastasis;
D O I
10.1016/j.lungcan.2004.06.014
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
F-18 fluorodeoxyglucose- positron emission tomography.(. PET) was investigated;in,patients with suspected residual disease or intrathoracic recurrence after pneumonectomy., Patients were identified from a prospective database. Impact of PET on staging and patient management was assessed. Clinical outcome was used to assess appropriateness of management. PET was performed in 17 cases, either post-operatively (n = 8), or later for suspected recurrence (n = 9) in patients with good performance status and without extensive disease on conventional imaging. PET changed treatment in 10 cases (59%). In five patients (29%), PET changed treatment intent (curative versus non-curative) from radical radiotherapy (RT) to palliative RT (n = 1), or observation or supportive care (n = 3), or from palliative to radical RT (n = 1). In a further patient with unexplained pain, PET appropriately showed no evidence of disease. In additional five cases (29%), PET influenced choice of RT dose and the use of concurrent chemotherapy (n = 3) or target volume (n = 2). Patients without tumour or with limited disease on PET had favourable outcomes whereas those with extensive disease suffered early tumour progression. PET was discordant with conventional assessment in > 50% of cases. PET may be valuable after `pneumonectomy if the patient is being considered for adjuvant or salvage radiotherapy although specificity may be reduced due to post-operative inflammatory changes. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:49 / 57
页数:9
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