Expression of GATA-3 in epidermis and hair follicle: Relationship to p63

被引：41

作者：

Chikh, Anissa

Sayan, Emre

Thibaut, Sebastien

Lena, Anna Maria

DiGiorgi, Sabrina

Bernard, Bruno A.

Melino, Gerry

Candi, Eleonora

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy

[2] Univ Leicester, Toxicol Unit, MRC, Leicester LE1 9HN, Leics, England

[3] Loreal Rech, F-75017 Clichy, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 361卷 / 01期

基金：

英国医学研究理事会;

关键词：

p63; p53; family; GATA-3; IKK alpha; hair follicle; epidermis;

D O I：

10.1016/j.bbrc.2007.06.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (Delta Np63) an amino-terminal transactivation domain, which contribution in skin formation is not fully understood. We found that p63 binds and transactivate GATA-3 promoter, which in turn transactivate IKK alpha, two pivotal regulators of epithelial development. Indeed, GATA-3 is a regulator of cell lineage in skin and hair follicles formation. To further study the relationship between GATA-3 and p63 isoforms here we investigated their expression during keratinocyte differentiation, in human epidermis and hair follicle. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1 / 6

页数：6

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