Access to new cytotoxic bisindole alkaloids by a modified borch reductive amination process

被引：12

作者：

Lewin, G

Schaeffer, C

Hocquemiller, R

Jacoby, E

Léonce, S

Pierré, A

Atassi, G

机构：

[1] Fac Pharm Chatenay Malabry, Lab Pharmacognosie, F-92296 Chatenay Malabry, France

[2] Inst Rech Servier, F-92150 Suresnes, France

来源：

HETEROCYCLES | 2000年 / 53卷 / 11期

关键词：

D O I：

10.3987/COM-00-9001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A slight modification of the Borch reductive amination method (delayed addition of NaBH3CN) was applied to an indole aldehyde compound, analog of the natural alkaloid, goniomitine. This reaction led to a series of new cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge.

引用

页码：2353 / +

页数：5

共 6 条

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