Association of Plasma Bilirubin Levels With Peripheral Arterial Disease in Chinese Hypertensive Patients: New Insight on Sex Differences

被引:4
作者
Shi, Yumeng [1 ,2 ]
Zhou, Wei [2 ,3 ]
Cheng, Mingshu [4 ]
Yu, Chao [2 ,3 ]
Wang, Tao [2 ,3 ]
Zhu, Lingjuan [2 ,3 ]
Bao, Huihui [1 ,2 ,3 ]
Hu, Lihua [5 ]
Li, Ping [1 ]
Cheng, Xiaoshu [1 ,2 ,3 ]
机构
[1] Nanchang Univ, Dept Cardiovasc Med, Affiliated Hosp 2, Nanchang, Peoples R China
[2] Jiangxi Prov Cardiovasc Dis Clin Med Res Ctr, Nanchang, Peoples R China
[3] Nanchang Univ, Ctr Prevent & Treatment Cardiovasc Dis, Affiliated Hosp 2, Nanchang, Peoples R China
[4] China Jiangxi Wuyuan Cty Fuchun Hosp, Shangrao, Peoples R China
[5] Peking Univ First Hosp, Dept Cardiovasc Med, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
total bilirubin; ankle-brachial index; peripheral arterial disease; hypertension; U-shaped curve; males; SERUM TOTAL BILIRUBIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; RISK; PREVALENCE; INDEX; METAANALYSIS; SEVERITY; HEALTH;
D O I
10.3389/fphys.2022.867418
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Background and aims: Previous studies have indicated that Plasma total bilirubin (TBiL) might play an essential role in peripheral arterial disease (PAD). However, the effects of different levels of TBiL on PAD development remain uncertain. We aimed to examine the TBiL and the prevalence of PAD among Chinese adults with hypertension, with particular attention paid to sex differences.Methods: A total of 10,900 hypertensive subjects were included in the current study. The mean age of our study participants was 63.86 +/- 9.25 years, and there were 5,129 males and 5,771 females. The outcome was peripheral arterial disease (PAD), defined as present when the ankle-brachial index (ABI) of either side was <= 0.90. The association between TBiL and PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: Of 10,900 hypertensive participants, 350 (3.21%) had PAD, and the mean plasma total bilirubin was 14.66 (6.86) mu mol/L. The mean TBiL was 15.67 mu mol/L in men and 13.76 mu mol/L in women. The smoothing curve showed that a U-shaped curve association existed between TBiL and the prevalence of PAD in Chinese adults with hypertension. When stratified by sex, TBiL was significantly U-shaped associated with PAD among men but not women. Among males, the inflection point was 11.48 mu mol/L; to the left inflection point, the effect size and 95% CI were 0.08, 0.01, 0.66, respectively; to the right inflection point, OR, 5.16; 95% CI,1.64, 16.25.Conclusions: We found an independent U-shaped association between TBiL and the prevalence of PAD among hypertensive subjects and a differential association between men and women. We further revealed a turning point by threshold effect analysis.
引用
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页数:8
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