Significance of human papillomavirus genotyping with high-grade cervical intraepithelial neoplasia treated by a loop electrosurgical excision procedure

被引：78

作者：

Kang, Woo Dae ^{[1
]}

Oh, Min Jeong ^{[1
]}

Kim, Seok Mo ^{[1
]}

Nam, Jong Hee ^{[2
]}

Park, Chang Soo ^{[2
]}

Choi, Ho Sun ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Obstet & Gynecol, Sch Med, Gwangu, South Korea

[2] Chonnam Natl Univ, Dept Pathol, Sch Med, Gwangu, South Korea

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 01期

关键词：

high-grade cervical intraepithelial neoplasia; high-risk human papillomavirus testing; loop electrosurgical excision procedure; POSITIVE MARGINS; NATURAL-HISTORY; FOLLOW-UP; CONIZATION; INFECTION; DISEASE; LESIONS;

D O I：

10.1016/j.ajog.2010.01.063

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: This study was conducted to determine whether the human papillomavirus (HPV) genotype by the HPV DNA chip test (HDC) is predictive of residual or recurrent high-grade cervical intraepithelial neoplasia (CIN) 2-3 following a loop electrosurgical excision procedure (LEEP). STUDY DESIGN: Between January 2001-February 2007, 672 patients with CIN2-3 were treated by a LEEP and followed up with cytology, the hybrid capture II assay, and the HDC. RESULTS: A total of 37 (5.5%) patients developed a recurrence, and those who developed a recurrence tested positive for the same high-risk (HR) HPV genotype before and after the LEEP. The same HR-HPV genotype by the HDC during the follow-up had a sensitivity and negative predictive value of 100% for detecting residual/recurrent disease. Persistent HPV-16 and HPV-18 were significantly associated with recurrent CIN2-3 (P < .05). CONCLUSION: Persistent infection with the same HR-HPV genotype, especially HPV-16 and HPV-18, should be considered a risk factor for developing residual/recurrent CIN2-3.

引用

页码：72.e1 / 72.e6

页数：6

共 20 条

[1] Pre- and post-conization high-risk HPV testing predicts residual/recurrent disease in patients treated for CIN 2-3 [J].