Long non-coding RNAs expression levels in diffuse large B-cell lymphoma: An in silico analysis

被引：12

作者：

Dousti, Fatemeh ^{[1
]}

Shahrisa, Arman ^{[2
]}

Ansari, Hossein ^{[3
]}

Hajjari, Mohammadreza ^{[4
]}

Birgani, Yaser Tahmasebi ^{[5
,6
]}

Mohammadiasl, Javad ^{[7
]}

Birgani, Maryam Tahmasebi ^{[7
,8
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Immunol, Ahvaz, Iran

[2] Tarbiat Modares Univ, Fac Biosci, Dept Mol Genet, Tehran, Iran

[3] Islamic Azad Univ, Dept Biotechnol, Ahvaz Branch, Ahvaz, Iran

[4] Shahid Chamran Univ Ahvaz, Fac Sci, Dept Genet, Ahvaz, Iran

[5] Ahvaz Jundishapur Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Ahvaz, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Environm Technol Res Ctr, Ahvaz, Iran

[7] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Med Genet, Ahvaz, Iran

[8] Ahvaz Jundishapur Univ Med Sci, Cellular & Mol Res Ctr, Ahvaz, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2018年 / 214卷 / 09期

关键词：

Diffuse large-B-cell lymphoma; Long noncoding RNA; GAS5; Biomarker; Bioinformatics analysis; LNCRNA GAS5; TRANSCRIPTOME; CANCER; BIOMARKERS;

D O I：

10.1016/j.prp.2018.08.006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Long non-coding RNAs (lncRNAs), are lengthy noncoding transcripts with pivotal roles in biological pathways including cell cycle, apoptosis and chromatin remodeling. Aberrant expression of lncRNAs has been strongly connected with tumor progression and metastasis. However, the prognostic significance of lncRNAs in diffuse large-B-cell lymphoma (DLBCL) remains unclear. In this study, the expression levels of 189 approved lncRNAs were considered in DLBCL patients using several different genomic and transcriptome datasets. The analyses showed that the lncRNA GAS5 allocated the maximum score of RNA dysregulation and can be considered as good choice in DLBCLs' researches.

引用

页码：1462 / 1466

页数：5

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