A procedure for generating locally identifiable reparameterisations of unidentifiable non-linear systems by the similarity transformation approach

被引:43
作者
Chappell, MJ [1 ]
Gunn, RN
机构
[1] Univ Warwick, Dept Engn, Coventry CV4 7AL, W Midlands, England
[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0NN, England
关键词
D O I
10.1016/S0025-5564(97)10004-9
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A method is presented for the generation of locally identifiable reparameterisations of non-linear systems which have been shown to be unidentifiable via application of the similarity transformation approach. The existence of the reparameterised system in terms of the maximum permissible number of locally identifiable parameters is provided and is crucially dependent upon the ability to find the rank deficiency of an appropriate (and possibly infinite) jacobian matrix. The reparameterisation procedure is described in detail, and is illustrated with application to two known non-trivial examples of unidentifiable non-linear systems. (C) 1998 Elsevier Science Inc. All rights reserved.
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页码:21 / 41
页数:21
相关论文
共 26 条
[1]   GLOBAL IDENTIFIABILITY OF THE PARAMETERS OF NONLINEAR-SYSTEMS WITH SPECIFIED INPUTS - A COMPARISON OF METHODS [J].
CHAPPELL, MJ ;
GODFREY, KR ;
VAJDA, S .
MATHEMATICAL BIOSCIENCES, 1990, 102 (01) :41-73
[2]   STRUCTURAL IDENTIFIABILITY OF THE PARAMETERS OF A NONLINEAR BATCH REACTOR MODEL [J].
CHAPPELL, MJ ;
GODFREY, KR .
MATHEMATICAL BIOSCIENCES, 1992, 108 (02) :241-251
[3]   STRUCTURAL IDENTIFIABILITY AND INDISTINGUISHABILITY OF CERTAIN 2-COMPARTMENT MODELS INCORPORATING NONLINEAR EFFLUX FROM THE PERIPHERAL COMPARTMENT [J].
CHAPPELL, MJ .
MATHEMATICAL BIOSCIENCES, 1995, 125 (01) :61-81
[4]   Structural identifiability of models characterizing saturable binding: Comparison of pseudo-steady-state and non-pseudo-steady-state model formulations [J].
Chappell, MJ .
MATHEMATICAL BIOSCIENCES, 1996, 133 (01) :1-20
[5]  
CHAPPELL MJ, 1990, 7 U WARW CONTR INSTR
[6]   NONLINEAR ADAPTIVE-CONTROL OF ADRENAL-POSTPITUITARY IMBALANCES AND IDENTIFIABILITY ANALYSIS [J].
CLAUDE, D ;
NADJAR, N .
MATHEMATICAL BIOSCIENCES, 1994, 121 (02) :155-192
[7]  
CLAUDE D, 1993, ECC93 GRON NETH, P2002
[8]  
COBELLI C, 1987, IDENTIFIABILITY PARA
[9]   COMPLETE PARAMETER BOUNDS AND QUASI-IDENTIFIABILITY CONDITIONS FOR A CLASS OF UNIDENTIFIABLE LINEAR-SYSTEMS [J].
DISTEFANO, JJ .
MATHEMATICAL BIOSCIENCES, 1983, 65 (01) :51-68
[10]  
Godfrey KR, 1987, IDENTIFIABILITY PARA