Gel-type autologous chondrocyte (Chondron™) implantation for treatment of articular cartilage defects of the knee

Background: Gel-type autologous chondrocyte (Chondron (TM)) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron (TM) at many clinical centers at various time points during the postoperative patient follow-up. Methods: Data from 98 patients with articular cartilage injury of the knee joint and who underwent Chondron (TM) implantation at ten Korean hospitals between January 2005 and November 2008, were included and were divided into two groups based on the patient follow-up period, i.e. 13 similar to 24-month follow-up and greater than 25-month follow-up. The telephone Knee Society Score obtained during telephone interviews with patients, was used as the evaluation tool. Results: On the tKSS-A (telephone Knee Society Score-A), the score improved from 43.52 +/- 20.20 to 89.71 +/- 13.69 (P < 0.05), and on the tKSS-B (telephone Knee Society Score-B), the score improved from 50.66 +/- 20.05 to 89.38 +/- 15.76 (P < 0.05). The total improvement was from 94.18 +/- 31.43 to 179.10 +/- 24.69 (P < 0.05). Conclusion: Gel-type autologous chondrocyte implantation for chondral knee defects appears to be a safe and effective method for both decreasing pain and improving knee function.