Clinical significance of melanoma-associated antigen A1-6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx

被引：1

作者：

Lee, Kang Dae ^{[1
]}

Lee, Hyoung Shin ^{[1
]}

Kim, Sung Won ^{[1
]}

Park, Taejung ^{[1
]}

Hong, Jong Chul ^{[2
]}

Chang, Hee Kyung ^{[3
]}

Jung, Sang Bong ^{[4
]}

Jeon, Chang-Ho ^{[5
]}

Park, Jong Wook ^{[6
]}

机构：

[1] Kosin Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, 34 Amnam Dong, Busan 602715, South Korea

[2] Dong A Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Busan, South Korea

[3] Kosin Univ, Coll Med, Dept Pathol, Busan 602715, South Korea

[4] Gimhae Coll, Dept Clin Pathol, Busan, South Korea

[5] Catholic Univ Daegu, Dept Lab Med, Sch Med, Daegu, South Korea

[6] Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷

关键词：

squamous cell carcinoma; larynx; hypopharynx; head and neck cancer; melanoma-associated antigen (MAGE); CANCER-TESTIS ANTIGENS; RT-NESTED PCR; NECK-CANCER; LUNG-CANCER; COMMON PRIMERS; MAGE A1-6; PROGNOSTIC RELEVANCE; TISSUE MICROARRAY; HEAD; DIAGNOSIS;

D O I：

10.1002/hed.24081

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Several studies have reported the expression of the melanoma-associated antigen (MAGE) gene in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the correlations between MAGE expression in sputum and the clinical features and oncologic outcomes of SCC of the larynx and hypopharynx. Methods. We performed a retrospective review of 119 patients treated for SCC of the larynx and hypopharynx and analysis of their induced sputum by nested reverse transcription-polymerase chain reaction (RT-PCR) to detect the MAGE-A1-6 gene. The associations between MAGE expression and clinical characteristics were analyzed. Results. Expression of MAGE-A1-6 in sputum was identified in 57 of 119 patients (47.9%), and was independently correlated to double primary cancer (p = .024; odds ratio [OR] = 4.135). Expression of MAGE-A1-6 in sputum was correlated to poor survival. Conclusion. Expression of MAGE-A1-6 in sputum predicts poor oncologic outcome in patients with SCC of the larynx and hypopharynx. (C) 2015 Wiley Periodicals, Inc.

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收藏

页码：E736 / E740

页数：5

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