Language recovery following subthalamic nucleus stimulation in Parkinson's disease

被引：24
作者：
Zanini, S
Melatini, A
Capus, L
Gioulis, M
Vassallo, A
Bava, A
机构：
[1] Univ Trieste, Dipartimento Fisiol & Patol, I-34127 Trieste, Italy
[2] Univ Trieste, Neurol Clin, I-34127 Trieste, Italy
[3] Osped Cattinara, UO Neurochirurg, Trieste, Italy
来源：
NEUROREPORT | 2003年 / 14卷 / 03期
关键词：
deep brain stimulation; implicit memory; language; Parkinson's disease; subthalamic nucleus;
D O I：
10.1097/01.wnr.0000058775.36017.86
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neuropsychological consequences of stimulation of the subthalamic nucleus for treatment of drug-resistant Parkinsons disease (PD) have been studied previously. However, no detailed investigations of linguistic function modifications have been carried out. We studied four consecutive patients with PD who underwent chronic bilateral stimulation of the subthalamic nuclei. Neuropsychological and linguistic evaluations were performed before and 2 weeks after surgery. Linguistic abilities were studied also 1 year after surgery with stimulators both off and on. Intraphrasal hesitation pauses, phonemic paraphasias and morpho-syntactic errors were significantly reduced and lexical retrieval improved with stimulation of the subthalamic nuclei. Implicit linguistic phenomena, mainly occurring within basal ganglia circuitry, benefited by recovery of functional equilibrium within basal nuclei and between overall basal ganglia circuitry and cerebral cortex.
引用
收藏
页码：511 / 516
页数：6
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