Human amniotic membrane grafts in therapy of chronic non-healing wounds

被引：51

作者：

Ilic, Dusko ^{[1
]}

Vicovac, Ljiljana ^{[2
]}

Nikolic, Milos ^{[3
]}

Ilic, Emilija Lazic ^{[4
]}

机构：

[1] Kings Coll London, Div Womens Hlth, Fac Life Sci & Med, Stem Cell Labs,Guys Assisted Concept Unit, London, England

[2] Univ Belgrade, Inst INEP, Reprod Biol Lab, Banatska 31B, Belgrade 11080, Serbia

[3] Univ Belgrade, Fac Med, Dept Dermatovenereol, Div Pediat Dermatol, Pasterova 2, Belgrade 11000, Serbia

[4] Mother & Child Healthcare Inst, Lab Cryobiol, Bone Marrow Transplantat Unit, Belgrade, Serbia

来源：

BRITISH MEDICAL BULLETIN | 2016年 / 117卷 / 01期

关键词：

human amniotic membrane; natural wound dressing; chronic wounds; diabetic foot ulcer; burns; recessive dystrophic epidermolysis bullosa; DIABETIC FOOT ULCERS; BIOLOGICAL-PROPERTIES; EPITHELIAL-CELLS; FETAL MEMBRANES; CLINICAL-TRIAL; REPAIR; MULTICENTER; ALLOGRAFTS; SUBSTRATE; COLLAGEN;

D O I：

10.1093/bmb/ldv053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Human amniotic membrane (HAM) has been embraced as a natural wound dressing almost exclusively in ophthalmology. Only recently, emergence of commercial HAM products prompted its use in growing range of indications, especially treatment of chronic non-healing wounds. Sources of data: ClinicalTrials.gov database and International Clinical Trials Registry Platform searched with key words 'human amniotic membrane' and 'chronic wounds'. Areas of agreement: HAM can be successfully used as a natural wound dressing to promote healing. Areas of controversy: It is still unclear, which preparation is more advantageous, cryopreserved HAM or dehydrated HAM. Growing points: There are an increasing number of commercial HAM products and clinical trials for a variety of dermatological diagnoses. Areas timely for developing research: In spite of easy procurement and low production costs, to our knowledge, there are currently only a few manufacturers of commercial HAM products tested in clinical trials for cutaneous wounds and all of them are located in the USA.

引用

页码：59 / 67

页数：9

共 42 条

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