Nitric oxide production inhibitory activity of clerodane diterpenes from Monoon membranifolium

被引：4

作者：

Polbuppha, Isaraporn ^{[1
,2
]}

Suthiphasilp, Virayu ^{[1
,2
]}

Maneerat, Tharakorn ^{[1
,2
,3
]}

Charoensup, Rawiwan ^{[3
,4
]}

Limtharakul, Thunwadee ^{[5
,6
]}

Cheenpracha, Sarot ^{[7
]}

Pyne, Stephen G. ^{[8
]}

Laphookhieo, Surat ^{[1
,2
,3
]}

机构：

[1] Mae Fah Luang Univ, Ctr Chem Innovat Sustainabil CIS, Chiang Rai, Thailand

[2] Mae Fah Luang Univ, Sch Sci, Chiang Rai, Thailand

[3] Luang Univ, Med Plant Innovat Ctr Mae Fah, Chiang Rai, Thailand

[4] Mae Fah Luang Univ, Sch Integrat Med, Chiang Rai, Thailand

[5] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai, Thailand

[6] Chiang Mai Univ, Fac Sci, Res Ctr Chem Dev Hlth Promoting Prod Northern Res, Chiang Mai, Thailand

[7] Univ Phayao, Sch Sci, Phayao, Thailand

[8] Univ Wollongong, Sch Chem & Mol Biosci, Wollongong, NSW, Australia

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 10期

关键词：

Monoon membranifolium; Annonaceae; clerodane diterpene; nitric oxide production inhibitory activity;

D O I：

10.1080/14786419.2021.1912044

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new clerodane diterpene, 2 beta-methoxyhardwickiic acid (1), and four known compounds (2-5) were isolated from the twigs of Monoon membranifolium. The structure of the new compound was determined by extensive spectroscopic methods and ESITOFMS data. The absolute configuration of 1 was established by a comparison of its ECD spectrum and specific rotation with those of related previously reported compounds. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in RAW264.7 macrophage cells. Compounds 3 and 5 inhibited NO production with IC50 values of 16.1 and 28.9 mu M, respectively, which were better than that of standard compound, indomethacin (IC50 = 32.2 mu M).

引用

页码：2513 / 2517

页数：5

共 17 条

[1] Four new diterpenoids from Ballota limbata [J].