Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

被引：127

作者：

Xu, Duo ^{[1
]}

Wu, Di ^{[1
]}

Qin, Meng ^{[2
,3
]}

Nih, Lina R. ^{[1
]}

Liu, Chaoyong ^{[1
,3
]}

Cao, Zheng ^{[1
]}

Ren, Jie ^{[1
]}

Chen, Xiangjun ^{[4
]}

He, Zhanlong ^{[5
,6
]}

Yu, Wenhai ^{[6
]}

Guan, Jiaoqiong ^{[6
]}

Duan, Suqin ^{[6
]}

Liu, Fang ^{[1
]}

Liu, Xiangsheng ^{[7
]}

Li, Jesse ^{[8
]}

Harley, Dushawn ^{[8
]}

Xu, Bin ^{[1
,9
]}

Hou, Lihua ^{[10
]}

Chen, Irvin S. Y. ^{[2
]}

Wen, Jing ^{[2
]}

Chen, Wei ^{[10
]}

Pourtaheri, Sina ^{[8
]}

Lu, Yunfeng ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, UCLA AIDS Inst, Los Angeles, CA 90095 USA

[3] Beijing Univ Chem Biotechnol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Coll Life Sci & Technol, Beijing 100029, Peoples R China

[4] Huashan Hosp, Dept Neurol, Shanghai 200040, Peoples R China

[5] Chinese Acad Med Sci, Inst Med Biol, Kunming 650118, Yunnan, Peoples R China

[6] Peking Union Med Coll, Kunming 650118, Yunnan, Peoples R China

[7] Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA 90095 USA

[9] Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China

[10] Beijing Inst Biotechnol, Beijing 100029, Peoples R China

来源：

ADVANCED MATERIALS | 2019年 / 31卷 / 33期

关键词：

blood-brain barrier; central nervous system; nerve growth factors; neural regeneration; spinal cord injury; BLOOD-BRAIN-BARRIER; SPINAL CORD BARRIER; NEUROTROPHIC FACTOR; DRUG-DELIVERY; GENE-THERAPY; NGF; NANOPARTICLES; PERMEABILITY; TRANSFERRIN; RECEPTORS;

D O I：

10.1002/adma.201900727

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood-brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule-based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases.

引用

页数：8

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