Nickel-Catalyzed Reductive Csp3-Ge Coupling of Alkyl Bromides with Chlorogermanes

被引：35

作者：

Guo, Peng ^{[1
,2
]}

Pang, Xiaobo ^{[1
]}

Wang, Ke ^{[1
]}

Su, Pei-Feng ^{[1
]}

Pan, Qiu-Quan ^{[1
]}

Han, Guan-Yu ^{[1
]}

Shen, Qian ^{[1
]}

Zhao, Zhen-Zhen ^{[1
]}

Zhang, Wenhua ^{[2
]}

Shu, Xing-Zhong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem SKLAOC, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ARYL HALIDES; OXIDATIVE ADDITION; ACCESS; FUNCTIONALIZATION; SILYLATION; GERMANIUM; BONDS;

D O I：

10.1021/acs.orglett.2c00207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive cross-coupling provides facile access to organogermanes, but it remains largely unexplored. Herein we report a nickel-catalyzed reductive Csp(3)-Ge coupling of alkyl bromides with chlorogermanes. This work has established a new method for producing alkylgermanes. The reaction proceeds under very mild conditions and tolerates various functionalities including ether, alcohol, alkene, nitrile, amine, ester, phosphonates, amides, ketone, and aldehyde. The application of this method to the modification of bioactive molecules is demonstrated.

引用

页码：1802 / 1806

页数：5

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