The ABCs of multidrug resistance in malaria

被引：73

作者：

Koenderink, Jan B. ^{[1
]}

Kavishe, Reginald A. ^{[2
]}

Rijpma, Sanna R. ^{[1
]}

Russel, Frans G. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pharmacol & Toxicol 149, NL-6500 HB Nijmegen, Netherlands

[2] Tumaini Univ, Kilimanjaro Christian Med Coll, Moshi, Tanzania

来源：

TRENDS IN PARASITOLOGY | 2010年 / 26卷 / 09期

关键词：

PLASMODIUM-FALCIPARUM MALARIA; SINGLE-NUCLEOTIDE POLYMORPHISMS; PFMDR1 COPY NUMBER; CHLOROQUINE RESISTANCE; DRUG-RESISTANCE; HETEROLOGOUS EXPRESSION; ARTEMETHER-LUMEFANTRINE; TRANSPORT PROTEINS; ANTIMALARIAL-DRUGS; PLASMA-MEMBRANE;

D O I：

10.1016/j.pt.2010.05.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Expanding drug resistance could become a major problem in malaria treatment, as only a limited number of effective antimalarials are available. Drug resistance has been associated with single nucleotide polymorphisms and an increased copy number of multidrug resistance protein 1 (MDR1), an ATP-binding cassette (ABC) protein family member. Many ABC transport proteins are membrane transporters that actively translocate a wide range of structurally and functionally diverse amphipathic compounds. The Plasmodium falciparum ABC family consists of 16 members and current knowledge of their physiological function and contribution to antimalarial drug resistance is limited. Here, we give an overview of the Plasmodium ABC family members with reference to their possible role in multidrug resistance.

引用

页码：440 / 446

页数：7

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