A cholinesterase genes server (ESTHER): A database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval

被引：40

作者：

Cousin, X

Hotelier, T

Lievin, P

Toutant, JP

Chatonnet, A

机构：

[1] INRA, DIFFERENCIAT CELLULAIRE & CROISSANCE, F-34060 MONTPELLIER, FRANCE

[2] INRA, CTR CALCUL, F-34060 MONTPELLIER, FRANCE

[3] INST PASTEUR, UNITE VENINS, F-75724 PARIS 15, FRANCE

来源：

NUCLEIC ACIDS RESEARCH | 1996年 / 24卷 / 01期

关键词：

D O I：

10.1093/nar/24.1.132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have built a database of sequences phylogenetically related to cholinesterases (ESTHER for esterases, alpha/beta hydrolase enzymes and relatives). These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) with some related proteins devoid of enzymatic activity. The purpose of ESTHER is to help comparison and alignment of any new sequence appearing in the field, to favour mutation analysis of structure-function relationships and to allow structural data recovery.

引用

页码：132 / 136

页数：5

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