Toxicity and immunological activity of silver nanoparticles

被引：57

作者：

Daniel, S. C. G. Kiruba ^{[2
]}

Tharmaraj, V.

Sironmani, T. Anitha ^{[1
]}

Pitchumani, K.

机构：

[1] Madurai Kamaraj Univ, Sch Biotechnol, Madurai 625021, Tamil Nadu, India

[2] Univ Madras, Dr ALM PG Inst Basic Med Sci, Madras 600113, Tamil Nadu, India

来源：

APPLIED CLAY SCIENCE | 2010年 / 48卷 / 04期

关键词：

Montmorillonite; Silver nanoparticles; Toxicity; Mice; GOLD NANOPARTICLES; CONTRAST; MECHANISMS; SAFETY; LIVER;

D O I：

10.1016/j.clay.2010.03.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the present study silver nanoparticles were synthesized and the biological distribution as well as the potential toxicity was studied. Two different concentrations of silver nanoparticles entrapped in montmorillonite were tested in Swiss mice. The animal study demonstrated that the Ag-(0)-montmorillonite was nontoxic, showed no immune response, exhibited increased blood half-life, crossed BBB and increased neurotransmission. These observations indicated that Ag-(0)-montmorillonite enables diverse applications in life sciences such as drug development, protein detection and gene delivery for any organs in broad, lungs and brain in particular. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：547 / 551

页数：5

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