HDAC inhibitors to the rescue in sonic hedgehog medulloblastoma

被引:5
作者
Becher, Oren J. [1 ,2 ,3 ,4 ]
机构
[1] Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA
[2] Northwestern Univ, Malnati Brain Tumor Ctr, Chicago, IL 60611 USA
[3] Northwestern Univ, Lurie Canc Ctr, Chicago, IL 60611 USA
[4] Northwestern Univ, Dept Biochem & Mol Genet, Chicago, IL 60611 USA
关键词
D O I
10.1093/neuonc/noz115
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1091 / 1092
页数:2
相关论文
共 10 条
[1]   Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma [J].
Coni, Sonia ;
Mancuso, Anna Barbara ;
Di Magno, Laura ;
Sdruscia, Giulia ;
Manni, Simona ;
Serrao, Silvia Maria ;
Rotili, Dante ;
Spiombi, Eleonora ;
Bufalieri, Francesca ;
Petroni, Marialaura ;
Kusio-Kobialka, Monika ;
De Smaele, Enrico ;
Ferretti, Elisabetta ;
Capalbo, Carlo ;
Mai, Antonello ;
Niewiadomski, Pawel ;
Screpanti, Isabella ;
Di Marcotullio, Lucia ;
Canettieri, Gianluca .
SCIENTIFIC REPORTS, 2017, 7
[2]   Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma [J].
Kieran, Mark W. ;
Chisholm, Julia ;
Casanova, Michela ;
Brandes, Alba A. ;
Aerts, Isabelle ;
Bouffet, Eric ;
Bailey, Simon ;
Leary, Sarah ;
MacDonald, Tobey J. ;
Mechinaud, Francoise ;
Cohen, Kenneth J. ;
Riccardi, Riccardo ;
Mason, Warren ;
Hargrave, Darren ;
Kalambakas, Stacey ;
Deshpande, Priya ;
Tai, Feng ;
Hurh, Eunju ;
Geoerger, Birgit .
NEURO-ONCOLOGY, 2017, 19 (11) :1542-1552
[3]   Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition [J].
Kool, Marcel ;
Jones, David T. W. ;
Jaeger, Natalie ;
Northcott, Paul A. ;
Pugh, Trevor J. ;
Hovestadt, Volker ;
Piro, Rosario M. ;
Esparza, L. Adriana ;
Markant, Shirley L. ;
Remke, Marc ;
Milde, Till ;
Bourdeaut, Franck ;
Ryzhova, Marina ;
Sturm, Dominik ;
Pfaff, Elke ;
Stark, Sebastian ;
Hutter, Sonja ;
Seker-Cin, Huriye ;
Johann, Pascal ;
Bender, Sebastian ;
Schmidt, Christin ;
Rausch, Tobias ;
Shih, David ;
Reimand, Jueri ;
Sieber, Laura ;
Wittmann, Andrea ;
Linke, Linda ;
Witt, Hendrik ;
Weber, Ursula D. ;
Zapatka, Marc ;
Koenig, Rainer ;
Beroukhim, Rameen ;
Bergthold, Guillaume ;
van Sluis, Peter ;
Volckmann, Richard ;
Koster, Jan ;
Versteeg, Rogier ;
Schmidt, Sabine ;
Wolf, Stephan ;
Lawerenz, Chris ;
Bartholomae, Cynthia C. ;
von Kalle, Christof ;
Unterberg, Andreas ;
Herold-Mende, Christel ;
Hofer, Silvia ;
Kulozik, Andreas E. ;
von Deimling, Andreas ;
Scheurlen, Wolfram ;
Felsberg, Joerg ;
Reifenberger, Guido .
CANCER CELL, 2014, 25 (03) :393-405
[4]   Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas [J].
Kool, Marcel ;
Korshunov, Andrey ;
Remke, Marc ;
Jones, David T. W. ;
Schlanstein, Maria ;
Northcott, Paul A. ;
Cho, Yoon-Jae ;
Koster, Jan ;
Schouten-van Meeteren, Antoinette ;
van Vuurden, Dannis ;
Clifford, Steven C. ;
Pietsch, Torsten ;
von Bueren, Andre O. ;
Rutkowski, Stefan ;
McCabe, Martin ;
Collins, V. Peter ;
Backlund, Magnus L. ;
Haberler, Christine ;
Bourdeaut, Franck ;
Delattre, Olivier ;
Doz, Francois ;
Ellison, David W. ;
Gilbertson, Richard J. ;
Pomeroy, Scott L. ;
Taylor, Michael D. ;
Lichter, Peter ;
Pfister, Stefan M. .
ACTA NEUROPATHOLOGICA, 2012, 123 (04) :473-484
[5]   A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma [J].
Pak, Ekaterina ;
MacKenzie, Ethan L. ;
Zhao, Xuesong ;
Pazyra-Murphy, Maria F. ;
Park, Paul M. C. ;
Wu, Lei ;
Shaw, Daniel L. ;
Addleson, Emily C. ;
Cayer, Suzanne S. ;
Lopez, Begona G-C ;
Agar, Nathalie Y. R. ;
Rubin, Lee L. ;
Qi, Jun ;
Merk, Daniel J. ;
Segal, Rosalind A. .
NEURO-ONCOLOGY, 2019, 21 (09) :1150-1163
[6]   Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor [J].
Robinson, Giles W. ;
Kaste, Sue C. ;
Chemaitilly, Wassim ;
Bowers, Daniel C. ;
Laughton, Stephen ;
Smith, Amy ;
Gottardo, Nicholas G. ;
Partap, Sonia ;
Bendel, Anne ;
Wright, Karen D. ;
Orr, Brent A. ;
Warner, William C. ;
Onar-Thomas, Arzu ;
Gajjar, Amar .
ONCOTARGET, 2017, 8 (41) :69295-69302
[7]   Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032 [J].
Robinson, Giles W. ;
Orr, Brent A. ;
Wu, Gang ;
Gururangan, Sridharan ;
Lin, Tong ;
Qaddoumi, Ibrahim ;
Packer, Roger J. ;
Goldman, Stewart ;
Prados, Michael D. ;
Desjardins, Annick ;
Chintagumpala, Murali ;
Takebe, Naoko ;
Kaste, Sue C. ;
Rusch, Michael ;
Allen, Sariah J. ;
Onar-Thomas, Arzu ;
Stewart, Clinton F. ;
Fouladi, Maryam ;
Boyett, James M. ;
Gilbertson, Richard J. ;
Curran, Tom ;
Ellison, David W. ;
Gajjar, Amar .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (24) :2646-U106
[8]   Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma [J].
Spiller, Susan E. ;
Ravanpay, Ali C. ;
Hahn, Andrew W. ;
Olson, James M. .
JOURNAL OF NEURO-ONCOLOGY, 2006, 79 (03) :259-270
[9]   Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine [J].
Taipale, J ;
Chen, JK ;
Cooper, MK ;
Wang, BL ;
Mann, RK ;
Milenkovic, L ;
Scott, MP ;
Beachy, PA .
NATURE, 2000, 406 (6799) :1005-1009
[10]   Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma [J].
Yauch, Robert L. ;
Dijkgraaf, Gerrit J. P. ;
Alicke, Bruno ;
Januario, Thomas ;
Ahn, Christina P. ;
Holcomb, Thomas ;
Pujara, Kanan ;
Stinson, Jeremy ;
Callahan, Christopher A. ;
Tang, Tracy ;
Bazan, J. Fernando ;
Kan, Zhengyan ;
Seshagiri, Somasekar ;
Hann, Christine L. ;
Gould, Stephen E. ;
Low, Jennifer A. ;
Rudin, Charles M. ;
de Sauvage, Frederic J. .
SCIENCE, 2009, 326 (5952) :572-574