Recovery of sensorineural hearing loss in congenital hypothyroidism

被引：0
作者：
Grandjean, A. [1 ,2 ]
Van Becelaere, T. [1 ,2 ]
Beckers, D. [3 ]
Eloy, P. [1 ,2 ]
Van Damme, J. P. [1 ,2 ]
Garin, P. [1 ,2 ]
Gilain, C. [1 ,2 ]
机构：
[1] CHU UCL Namur, HNS & ENT Dept, Ave Gaston Therasse 1, B-5530 Yvoir, Belgium
[2] CHU UCL Namur, Audiophonol Ctr, Yvoir, Belgium
[3] CHU UCL Namur, Paediat Dept, Yvoir, Belgium
来源：
B-ENT | 2017年 / 13卷 / 02期
关键词：
Congenital hypothyroidism; sensorineural hearing loss; neonatal screening; hearing recovery; hormonal replacement therapy; COCHLEAR HAIR-CELLS; THYROID-HORMONE; ONSET; BETA; ERA;
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Congenital hypothyroidism (CH) may generate serious neurologic complications in children. Sensorineural deafness is one of them, but can be prevented with prompt hormonal substitution. Case report: The unusual case of an infant with sensorineural hearing loss associated with severe CH is reported. The infant recovered after adequate hormonal substitution, with thyroid hormone (TH) administered as late as 8 months after birth. The role of TH in auditory function and the underlying mechanisms that can lead to hearing loss in CH are discussed. Conclusion: This case illustrates the possible association between sensorineural hearing loss and severe CH. Systematic checks of thyroid dysfunction in newborns are important. Despite systematic screening, errors may occur in the transmission of the results, leading to severe complications. Fortunately, sensorineural hearing loss may be recovered after delayed but adequate hormonal substitution.
引用
收藏
页码：113 / 118
页数：6
相关论文
共 16 条
  • [1] Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism
    Bruno, Rocco
    Aversa, Tommaso
    Catena, Mariaausilia
    Valenzise, Mariella
    Lombardo, Fortunato
    De Luca, Filippo
    Wasniewska, Malgorzata
    [J]. HEARING RESEARCH, 2015, 327 : 43 - 47
  • [2] Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells
    Dettling, Juliane
    Franz, Christoph
    Zimmermann, Ulrike
    Lee, Sze Chim
    Bress, Andreas
    Brandt, Niels
    Feil, Robert
    Pfister, Markus
    Engel, Jutta
    Flamant, Frederic
    Ruettiger, Lukas
    Knipper, Marlies
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2014, 382 (01) : 26 - 37
  • [3] Long-term consequences of congenital hypothyroidism in the era of screening programmes
    Grüters, A
    Jenner, A
    Krude, H
    [J]. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 16 (02) : 369 - 382
  • [4] Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment
    Huo, Kaiming
    Zhang, Zhan
    Zhao, Dehua
    Li, Hezhou
    Wang, Jun
    Wang, Xinxia
    Feng, Hongqi
    Wang, Xiaoyang
    Zhu, Changlian
    [J]. ENDOCRINE JOURNAL, 2011, 58 (05) : 355 - 361
  • [5] Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice
    Karolyi, I. Jill
    Dootz, Gary A.
    Halsey, Karin
    Beyer, Lisa
    Probst, Frank J.
    Johnson, Kenneth R.
    Parlow, Albert F.
    Raphael, Yehoash
    Dolan, David F.
    Camper, Sally A.
    [J]. MAMMALIAN GENOME, 2007, 18 (08) : 596 - 608
  • [6] Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems
    Knipper, M
    Zinn, C
    Maier, H
    Praetorius, M
    Rohbock, K
    Köpschall, I
    Zimmermann, U
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (05) : 3101 - 3112
  • [7] Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of β-tectorin protein in the tectorial membrane -: Implication for hearing loss
    Knipper, M
    Richardson, G
    Mack, A
    Müller, M
    Goodyear, R
    Limberger, A
    Rohbock, K
    Köpschall, I
    Zenner, HP
    Zimmermann, U
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) : 39046 - 39052
  • [8] Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1
    Ng, Lily
    Cordas, Emily
    Wu, Xuefeng
    Vella, Kristen R.
    Hollenberg, Anthony N.
    Forrest, Douglas
    [J]. ENDOCRINOLOGY, 2015, 156 (10) : 3853 - 3865
  • [9] Congenital hypothyroidism
    Rastogi, Maynika V.
    LaFranchi, Stephen H.
    [J]. ORPHANET JOURNAL OF RARE DISEASES, 2010, 5
  • [10] Rose SR, 2015, PEDIACTRICS, V117, P2290
12