Carbohydrate chain terminators: Rational design of novel carbohydrate-based antifungal agents

被引：12
作者：
Danac, Ramona
Ball, Lucy
Gurr, Sarah J.
Muller, Thierry
Fairbanks, Antony J.
机构：
[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England
[2] Univ Oxford, Dept Plant Sci, Oxford OX1 3RB, England
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 11期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1002/cbic.200700234
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(Chemical Equation Presented) The terminators. A chain-termination approach was employed to rationally design monosaccharide derivatives as inhibitors of chitin biosynthesis by replacement of the 4-hydroxyl group of N-acetyl glucosamine monomers. Antifungal activity was observed for a variety of acylated monosaccharide and oxazoline derivatives by means of fungal-spore germination and adhesion assays. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1241 / 1245
页数：5
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