Aging in the Brain: New Roles of Epigenetics in Cognitive Decline

被引：74
作者：
Barter, Jolie D. [1 ]
Foster, Thomas C. [1 ,2 ]
机构：
[1] Univ Florida, McKnight Brain Inst, Dept Neurosci, 1149 South Newell Dr,POB 100244, Gainesville, FL 32610 USA
[2] Univ Florida, Genet & Genom Program, Gainesville, FL 32610 USA
来源：
NEUROSCIENTIST | 2018年 / 24卷 / 05期
关键词：
aging; memory; cognition; epigenetics; DNA methylation; neuroinflammation; microRNA; histone modifications; HISTONE DEACETYLASE INHIBITORS; ESTROGEN-RECEPTOR-ALPHA; AGE-RELATED-CHANGES; DNA METHYLATION; MEMORY FORMATION; HIPPOCAMPUS; TRANSCRIPTION; PROTEIN; ACETYLATION; EXPRESSION;
D O I：
10.1177/1073858418780971
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Gene expression in the aging brain depends on transcription signals generated by senescent physiology, interacting with genetic and epigenetic programs. In turn, environmental factors influence epigenetic mechanisms, such that an epigenetic-environmental link may contribute to the accumulation of cellular damage, susceptibility or resilience to stressors, and variability in the trajectory of age-related cognitive decline. Epigenetic mechanisms, DNA methylation and histone modifications, alter chromatin structure and the accessibility of DNA. Furthermore, small non-coding RNA, termed microRNA (miRNA) bind to messenger RNA (mRNA) to regulate translation. In this review, we examine key questions concerning epigenetic mechanisms in regulating the expression of genes associated with brain aging and age-related cognitive decline. In addition, we highlight the interaction of epigenetics with senescent physiology and environmental factors in regulating transcription.
引用
收藏
页码：516 / 525
页数：10
相关论文
共 67 条
[61]   A brain-specific microRNA regulates dendritic spine development [J].
Schratt, GM ;
Tuebing, F ;
Nigh, EA ;
Kane, CG ;
Sabatini, ME ;
Kiebler, M ;
Greenberg, ME .
NATURE, 2006, 439 (7074) :283-289
[62]   Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging [J].
Sewal, Angila S. ;
Patzke, Holger ;
Perez, Evelyn J. ;
Park, Pul ;
Lehrmann, Elin ;
Zhang, Yongqing ;
Becker, Kevin G. ;
Fletcher, Bonnie R. ;
Long, Jeffrey M. ;
Rapp, Peter R. .
JOURNAL OF NEUROSCIENCE, 2015, 35 (33) :11729-11742
[63]   microRNAs in neurons: manifold regulatory roles at the synapse [J].
Siegel, Gabriele ;
Saba, Reuben ;
Schratt, Gerhard .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2011, 21 (04) :491-497
[64]   Histone Deacetylase 2 Inhibition Attenuates Downregulation of Hippocampal Plasticity Gene Expression during Aging [J].
Singh, Padmanabh ;
Thakur, M. K. .
MOLECULAR NEUROBIOLOGY, 2018, 55 (03) :2432-2442
[65]   H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus [J].
Snigdha, Shikha ;
Prieto, G. Aleph ;
Petrosyan, Arpine ;
Loertscher, Brad M. ;
Dieskau, Andre P. ;
Overman, Larry E. ;
Cotman, Carl W. .
JOURNAL OF NEUROSCIENCE, 2016, 36 (12) :3611-3622
[66]   Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins [J].
Starnawska, Anna ;
Tan, Qihua ;
McGue, Matt ;
Mors, Ole ;
Borglum, Anders D. ;
Christensen, Kaare ;
Nyegaard, Mette ;
Christiansen, Lene .
FRONTIERS IN AGING NEUROSCIENCE, 2017, 9
[67]   DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer [J].
Stone, Andrew ;
Zotenko, Elena ;
Locke, Warwick J. ;
Korbie, Darren ;
Millar, Ewan K. A. ;
Pidsley, Ruth ;
Stirzaker, Clare ;
Graham, Peter ;
Trau, Matt ;
Musgrove, Elizabeth A. ;
Nicholson, Robert I. ;
Gee, Julia M. W. ;
Clark, Susan J. .
NATURE COMMUNICATIONS, 2015, 6
1234567