Prospects of Genetics and Epigenetics of Alcohol Use Disorder

被引：3

作者：

Wedemeyer, Friederike ^{[1
]}

Kaminski, Jakob A. ^{[1
,2
,3
,4
,5
]}

Zillich, Lea ^{[6
]}

Hall, Alisha S. M. ^{[6
]}

Friedel, Eva ^{[1
,2
,3
,4
,5
]}

Witt, Stephanie H. ^{[6
]}

机构：

[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite Campus Mitte CCM, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] Berlin Inst Hlth BIH, Berlin, Germany

[6] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany

来源：

CURRENT ADDICTION REPORTS | 2020年 / 7卷 / 04期

关键词：

Alcohol use disorder; Addiction; Genetics; Epigenetics; Neurobiology; Personalized medicine; EPIGENOME-WIDE ASSOCIATION; DNA METHYLATION; GLUCOCORTICOID-RECEPTOR; RISK SCORES; LIFE-SPAN; DEPENDENCE; BRAIN; MECHANISMS; SCHIZOPHRENIA; INTOXICATION;

D O I：

10.1007/s40429-020-00331-x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Purpose of ReviewIn this study, we illustrate recent findings regarding the genetics and epigenetics of alcohol use disorder (AUD). We further outline the future direction of genetic and epigenetic research in AUD.Recent FindingsRecent genome- and epigenome-wide studies allow new insight into genetic and epigenetic variation associated with AUD. The largest EWAS of AUD so far/to date found evidence for altered glucocorticoid receptor regulation. Longitudinal studies provide insight into the dynamics of the disease. Analyses of postmortem brain tissue reveal the impact of chronic alcohol consumption on DNA methylation in the brain.SummaryGenetic and environmental factors-mediated via epigenetic mechanisms-play an important role in AUD. Although knowledge of the biological underpinnings of AUD is still limited, ongoing research will ultimately lead to the development of biomarkers for disease classification, course of disease, and treatment response to support personalized medicine in the future.

引用

页码：446 / 452

页数：7

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