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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine B-coronavirus-induced neuroinflammation
被引:6
作者:

Sengupta, Sourodip
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Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India

Addya, Sankar
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机构:
Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA USA Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India

Biswas, Diptomit
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机构:
Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India

Banerjee, Paromita
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Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India

Sarma, Jayasri Das
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机构:
Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India
机构:
[1] Indian Inst Sci Educ & Res Kolkata IISER K, Dept Biol Sci, Mohanpur, India
[2] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA USA
来源:
关键词:
beta-coronavirus (beta-CoV);
MHV-A59;
MMPs;
ROS;
TIMPs;
Neuroinflammation;
NF-KAPPA-B;
SPIKE PROTEIN;
MULTIPLE-SCLEROSIS;
VIRUS ENTRY;
ACTIVATION;
CELL;
EXPRESSION;
CLEAVAGE;
SYSTEM;
SARS;
D O I:
10.1016/j.virol.2021.11.012
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Mouse hepatitis virus (MHV; m-B-CoV) serves as a useful model for studying the cellular factors involved in neuroinflammation. To understand the role of matrix metalloproteinases (MMPs) in neuroinflammation, brain tissues from m-B-CoV-infected mice were harvested at different days post-infection (d.p.i) and investigated for Mmp expression by RT-qPCR. Mmp-2,-3,-8,-12 showed significant mRNA upregulation peaking with viral replication between 5 and 6 d.p.i. Elevated levels of MMP regulator TIMP-1 are suggestive of a TIMP-1 mediated host antiviral response. Biological network assessment suggested a direct involvement of MMP-3,-8,-14 in facilitating peripheral leukocyte infiltrations. Flow cytometry confirmed the increased presence of NK cells, CD4(+) and CD8(+) T cells, neutrophils, and MHCII expressing cells in the m-B-CoV infected mice brain. Our study revealed that m-B-CoV upregulated Park7, RelA, Nrf2, and Hmox1 transcripts involved in ROS production and antioxidant pathways, describing the possible nexus between oxidative pathways, MMPs, and TIMP in m-B-CoV-induced neuroinflammation.
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页码:122 / 135
页数:14
相关论文
共 74 条
[1]
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice
[J].
Ami, Yasushi
;
Nagata, Noriyo
;
Shirato, Kazuya
;
Watanabe, Rie
;
Iwata, Naoko
;
Nakagaki, Keiko
;
Fukushi, Shuetsu
;
Saijo, Masayuki
;
Morikawa, Shigeru
;
Taguchi, Fumihiro
.
MICROBIOLOGY AND IMMUNOLOGY,
2008, 52 (02)
:118-127

Ami, Yasushi
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Nagata, Noriyo
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Shirato, Kazuya
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Watanabe, Rie
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Iwata, Naoko
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Nakagaki, Keiko
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Fukushi, Shuetsu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Saijo, Masayuki
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Morikawa, Shigeru
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan

Taguchi, Fumihiro
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan Natl Inst Infect Dis, Dept Virol 3, Div Respiratory Virus Dis, Murayama Branch, Tokyo 2080011, Japan
[2]
Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain
[J].
Belouzard, Sandrine
;
Madu, Ikenna
;
Whittaker, Gary R.
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2010, 285 (30)
:22756-22761

论文数: 引用数:
h-index:
机构:

Madu, Ikenna
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

Whittaker, Gary R.
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Microbiol & Immunol, Ithaca, NY 14853 USA Cornell Univ, Dept Microbiol & Immunol, Ithaca, NY 14853 USA
[3]
Pathogenesis of Murine Coronavirus in the Central Nervous System
[J].
Bender, Susan J.
;
Weiss, Susan R.
.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY,
2010, 5 (03)
:336-354

Bender, Susan J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

Weiss, Susan R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
[4]
Coronavirus infection of the central nervous system: host-virus stand-off
[J].
Bergmann, CC
;
Lane, TE
;
Stohlman, SA
.
NATURE REVIEWS MICROBIOLOGY,
2006, 4 (02)
:121-132

Bergmann, CC
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Cleveland, OH 44195 USA

Lane, TE
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Cleveland, OH 44195 USA

Stohlman, SA
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Cleveland, OH 44195 USA
[5]
Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease
[J].
Bertram, Stephanie
;
Glowacka, Ilona
;
Mueller, Marcel A.
;
Lavender, Hayley
;
Gnirss, Kerstin
;
Nehlmeier, Inga
;
Niemeyer, Daniela
;
He, Yuxian
;
Simmons, Graham
;
Drosten, Christian
;
Soilleux, Elizabeth J.
;
Jahn, Olaf
;
Steffen, Imke
;
Poehlmann, Stefan
.
JOURNAL OF VIROLOGY,
2011, 85 (24)
:13363-13372

Bertram, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Virol, D-3000 Hannover, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Glowacka, Ilona
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Virol, D-3000 Hannover, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Mueller, Marcel A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Virol, Med Ctr, D-5300 Bonn, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Lavender, Hayley
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Gnirss, Kerstin
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Virol, D-3000 Hannover, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Nehlmeier, Inga
论文数: 0 引用数: 0
h-index: 0
机构: German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Niemeyer, Daniela
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Virol, Med Ctr, D-5300 Bonn, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

He, Yuxian
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R China German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Simmons, Graham
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Drosten, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Inst Virol, Med Ctr, D-5300 Bonn, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Soilleux, Elizabeth J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England
John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Jahn, Olaf
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Expt Med, Prote Grp, D-37075 Gottingen, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Steffen, Imke
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Inst Virol, D-3000 Hannover, Germany
Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany

Poehlmann, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany
Hannover Med Sch, Inst Virol, D-3000 Hannover, Germany German Primate Ctr, Infect Biol Unit, D-37077 Gottingen, Germany
[6]
Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells
[J].
Bond, M
;
Chase, AJ
;
Baker, AH
;
Newby, AC
.
CARDIOVASCULAR RESEARCH,
2001, 50 (03)
:556-565

Bond, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England

Chase, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England

Baker, AH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England

Newby, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England
[7]
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide
[J].
Bosch, Berend Jan
;
Bartelink, Willem
;
Rottier, Peter J. M.
.
JOURNAL OF VIROLOGY,
2008, 82 (17)
:8887-8890

Bosch, Berend Jan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, Div Virol, NL-3508 TD Utrecht, Netherlands

Bartelink, Willem
论文数: 0 引用数: 0
h-index: 0
机构: Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, Div Virol, NL-3508 TD Utrecht, Netherlands

Rottier, Peter J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, Div Virol, NL-3508 TD Utrecht, Netherlands Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, Div Virol, NL-3508 TD Utrecht, Netherlands
[8]
Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis
[J].
Butchi, Niranjan
;
Kapil, Parul
;
Puntambekar, Shweta
;
Stohlman, Stephen A.
;
Hinton, David R.
;
Bergmann, Cornelia C.
.
JOURNAL OF VIROLOGY,
2015, 89 (18)
:9299-9312

Butchi, Niranjan
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

Kapil, Parul
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

Puntambekar, Shweta
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

Stohlman, Stephen A.
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

Hinton, David R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

Bergmann, Cornelia C.
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA
[9]
Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases
[J].
Cauwe, Benedicte
;
Opdenakker, Ghislain
.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY,
2010, 45 (05)
:351-423

Cauwe, Benedicte
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leuven, Rega Inst Med Res, Immunobiol Lab, Minderbroedersstr 10, B-3000 Louvain, Belgium Univ Leuven, Rega Inst Med Res, Immunobiol Lab, Minderbroedersstr 10, B-3000 Louvain, Belgium

Opdenakker, Ghislain
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leuven, Rega Inst Med Res, Immunobiol Lab, Minderbroedersstr 10, B-3000 Louvain, Belgium Univ Leuven, Rega Inst Med Res, Immunobiol Lab, Minderbroedersstr 10, B-3000 Louvain, Belgium
[10]
CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation
[J].
Chakravarty, Debanjana
;
Saadi, Fareeha
;
Kundu, Soumya
;
Bose, Abhishek
;
Khan, Reas
;
Dine, Kimberly
;
Kenyon, Lawrence C.
;
Shindler, Kenneth S.
;
Das Sarma, Jayasri
.
JOURNAL OF VIROLOGY,
2020, 94 (14)

Chakravarty, Debanjana
论文数: 0 引用数: 0
h-index: 0
机构:
Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

论文数: 引用数:
h-index:
机构:

Kundu, Soumya
论文数: 0 引用数: 0
h-index: 0
机构:
Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Bose, Abhishek
论文数: 0 引用数: 0
h-index: 0
机构:
Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Khan, Reas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Dine, Kimberly
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Kenyon, Lawrence C.
论文数: 0 引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Shindler, Kenneth S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA
Univ Penn, Scheie Eye Inst, Dept Neurol, Philadelphia, PA 19104 USA Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India

Das Sarma, Jayasri
论文数: 0 引用数: 0
h-index: 0
机构:
Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India
Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA Indian Inst Sci Educ & Res Kolkata, Dept Biol Sci, Mohanpur, India