FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis

被引：15

作者：

Scazzone, Concetta ^{[1
]}

Agnello, Luisa ^{[1
]}

Lo Sasso, Bruna ^{[1
]}

Salemi, Giuseppe ^{[2
]}

Gambino, Caterina Maria ^{[1
]}

Ragonese, Paolo ^{[2
]}

Candore, Giuseppina ^{[3
]}

Ciaccio, Anna Maria ^{[4
]}

Giglio, Rosaria Vincenza ^{[1
]}

Bivona, Giulia ^{[1
]}

Vidali, Matteo ^{[5
]}

Ciaccio, Marcello ^{[1
,6
]}

机构：

[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Inst Clin Biochem Clin Mol Med & Lab Med, I-90127 Palermo, Italy

[2] Univ Palermo, Unit Neurol, Dept Biomed Neurosci & Adv Diagnost, I-90127 Palermo, Italy

[3] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Lab Immunopathol & Immunosenescence, I-90127 Palermo, Italy

[4] Univ Palermo, Unit Clin Biochem, I-90127 Palermo, Italy

[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, I-20122 Milan, Italy

[6] Azienda Osped Univ Policlin P Giaccone, Dept Lab Med, I-90127 Palermo, Italy

来源：

BRAIN SCIENCES | 2021年 / 11卷 / 04期

关键词：

multiple sclerosis; genetic; polymorphisms; FOXP3; GATA3; vitamin D; REGULATORY T-CELLS; SINGLE-NUCLEOTIDE POLYMORPHISMS; MYELIN BASIC-PROTEIN; 25-HYDROXYVITAMIN D; GENE POLYMORPHISM; DISEASE; ASSOCIATION; SUSCEPTIBILITY; RISK; INFLAMMATION;

D O I：

10.3390/brainsci11040415

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3 gene polymorphisms have been associated with the susceptibility to autoimmune diseases. The expression of Foxp3 in Tregs is regulated by the transcription factor GATA binding-protein 3 (GATA3) and vitamin D-3. The aim of this retrospective case-control study was to investigate the potential association between FOXP3 and GATA3 genetic variants, Vitamin D-3, and MS risk. Methods: We analyzed two polymorphisms in the FOXP3 gene (rs3761547 and rs3761548) and a polymorphism in the GATA3 gene (rs3824662) in 106 MS patients and 113 healthy controls. Serum 25(OH)D3 was also measured in all participants. Results: No statistically significant genotypic and allelic differences were found in the distribution of FOXP3 rs3761547 and rs3761548, or GATA3 rs3824662 in the MS patients, compared with controls. Patients that were homozygous for rs3761547 had lower 25(OH)D3 levels. Conclusions: Our findings did not show any association among FOXP3 and GATA3 SNPs, vitamin D-3, and MS susceptibility.

引用

页数：9

共 48 条

[11]

Eftekharian Mohammad Mahdi, 2016, Human Antibodies, V24, P85, DOI 10.3233/HAB-160299

[12] Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis [J].