Immunodominant minor histocompatibility antigens: the major ones

被引：59
作者：
Perreault, C
Roy, DC
Fortin, C
机构：
[1] Hop Maison Neuve Rosemont, Res Ctr, Quebec City, PQ H1T 2M4, Canada
[2] Univ Laval, Ecole Psychol, Quebec City, PQ G1K 7P4, Canada
来源：
IMMUNOLOGY TODAY | 1998年 / 19卷 / 02期
关键词：
D O I：
10.1016/S0167-5699(97)01185-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Minor histocompatibility antigens (MiHAs) are extremely numerous - possibly up to 720 in mice - and have been regarded as an 'immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant MiHAs, rather than polyclonal. This concept has important implications in transplantation and cancer immunotherapy.
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页码：69 / 74
页数：6
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