Musk-antibody positive myasthenia gravis presenting with isolated neck extensor weakness

被引：10

作者：

Casasnovas, C. ^{[1
]}

Povedano, M. ^{[1
]}

Jauma, S. ^{[1
]}

Montero, J. ^{[1
]}

Martinez-Matos, J. A. ^{[1
]}

机构：

[1] Hosp Univ Bellvitge IDIBELL, Hosp Llobregat, Dept Neurol, Neuromuscular Unit, Barcelona 08907, Spain

来源：

NEUROMUSCULAR DISORDERS | 2007年 / 17卷 / 07期

关键词：

anti-MuSK; seronegative; myasthenia gravis; MG; dropped head; extensor neck weakness;

D O I：

10.1016/j.nmd.2007.03.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dropped head sign is characterized by the gradual forward sagging of the head due to weakness of neck extensor muscles. This may be a prominent sign of several neuromuscular disorders and may be an isolated feature of myasthenia gravis (MG). We describe a patient with isolated neck extensor weakness, eletrophysio logical findings suggesting myasthenia gravis and positive MuSK antibodies. This case supports that finding anti-MuSK antibodies may be extremely helpful in dropped head patients and negative acetylcholine receptor antibodies especially if needle EMG does not reveal myopathic or neurogenic patterns. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：544 / 546

页数：3

共 11 条

[1]

Biran I, 1999, MUSCLE NERVE, V22, P769, DOI 10.1002/(SICI)1097-4598(199906)22:6<769::AID-MUS15>3.0.CO

[2]

2-D

[3] Early or late appearance of "dropped head syndrome" in amyotrophic lateral sclerosis [J].

Gourie-Devi, M ;

Nalini, A ;

Sandhya, S .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (05) :683-686

[4] THE DROPPED HEAD SYNDROME WITH CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY [J].

HOFFMAN, D ;

GUTMANN, L .

MUSCLE & NERVE, 1994, 17 (07) :808-810

[5] Isolated neck extensor myopathy: A common cause of dropped head syndrome [J].

Katz, JS ;

Wolfe, GI ;

Burns, DK ;

Bryan, WW ;

Fleckenstein, JL ;

Barohn, RJ .

NEUROLOGY, 1996, 46 (04) :917-921

[6]

Lomen-Hoerth C, 1999, MUSCLE NERVE, V22, P1146, DOI 10.1002/(SICI)1097-4598(199908)22:8<1146::AID-MUS23>3.0.CO

[7]

2-U

[8]

Okano Tomoko, 2006, Rinsho Shinkeigaku, V46, P496

[9] The dropped head sign: an unusual presenting feature of myasthenia gravis [J].

Puruckherr, M ;

Pooyan, P ;

Dube, D ;

Byrd, RP ;

Roy, TM .

NEUROMUSCULAR DISORDERS, 2004, 14 (06) :378-379

[10] MuSK-antibody positive myasthenia gravis: Clinical and electrodiagnostic patterns [J].

Stickler, DE ;

Massey, JM ;

Sanders, DB .

CLINICAL NEUROPHYSIOLOGY, 2005, 116 (09) :2065-2068

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