Regulation of AMPA receptors by phosphorylation

被引：68

作者：

Carvalho, AL ^{[1
]}

Duarte, CB ^{[1
]}

Carvalho, AP ^{[1
]}

机构：

[1] Univ Coimbra, Dept Zool, Ctr Neurosci Coimbra, P-3004517 Coimbra, Portugal

来源：

NEUROCHEMICAL RESEARCH | 2000年 / 25卷 / 9-10期

关键词：

AMPA receptors; protein kinase C; protein kinase A; Ca2+/calmodulin-dependent protein kinase II; synaptic plasticity; protein phosphatases;

D O I：

10.1023/A:1007644128886

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions. Recent studies have shown that phosphorylation of AMPA receptors by cAMP-dependent protein kinase (PKA) and Ca2+ - and calmodulin-dependent protein kinase II (CaMKII) potentiates their activity, but phosphorylation of the receptor subunits may also affect their interaction with intracellular proteins, and their expression at the plasma membrane. Phosphorylation of AMPA receptor subunits has also been investigated in relation to processes of synaptic plasticity. This review focuses on recent advances in understanding the molecular mechanisms of regulation of AMPA receptors, and their implications in synaptic plasticity.

引用

页码：1245 / 1255

页数：11

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