Piperazirum, a novel bioactive alkaloid from Arum palaestinum Boiss.

被引：18
作者：
El-Desouky, S. K.
Ryu, Shi Young
Kim, Young-Kyoon
机构：
[1] Kookmin Univ, Coll Forest Sci, Seoul 136702, South Korea
[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 23期
关键词：
Arum palaestinum; Araceae; cytotoxicity; 3; alpha; 5; alpha-diisobutyr-yl-6; alpha-isopropyl-piperazine-2-one; NMR;
D O I：
10.1016/j.tetlet.2007.04.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel alkylated piperazine (3 alpha,5 alpha-diisobutyryl-6 alpha-isopropyl-piperazine-2-one, 1) has been isolated from the n-butanol soluble part of the leaves extract of Arum palaestinum Boiss., the chemical structure and the relative stereochemistry of 1 were elucidated on the basis of 1D and 2D NMR spectroscopic data. Piperazirum showed a significant cytotoxicity against cultured tumor cell lines in vitro. (c) 2007 Published by Elsevier Ltd.
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收藏
页码：4015 / 4017
页数：3
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