Hereditary and Familial Colon Cancer

被引：919

作者：

Jasperson, Kory W. ^{[1
]}

Tuohy, Therese M. ^{[1
]}

Neklason, Deborah W. ^{[2
]}

Burt, Randall W. ^{[1
,3
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Med, Salt Lake City, UT 84112 USA

来源：

GASTROENTEROLOGY | 2010年 / 138卷 / 06期

关键词：

Familial Colon Cancer; Lynch Syndrome; Hereditary Polyposis Conditions; NONPOLYPOSIS COLORECTAL-CANCER; GENOME-WIDE ASSOCIATION; ADENOMATOUS POLYPOSIS; LYNCH-SYNDROME; SUSCEPTIBILITY LOCUS; GYNECOLOGIC CANCERS; GSTT1; POLYMORPHISMS; RISK; MUTATIONS; COMMON;

D O I：

10.1053/j.gastro.2010.01.054

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Clarification of predisposing genes allows for accurate risk assessment and more precise screening approaches. This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines.

引用

页码：2044 / 2058

页数：15

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