Dietary Natural Products for Prevention and Treatment of Liver Cancer

被引：211
作者：
Zhou, Yue [1 ]
Li, Ya [1 ]
Zhou, Tong [1 ]
Zheng, Jie [1 ]
Li, Sha [3 ]
Li, Hua-Bin [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China
[3] Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
来源：
NUTRIENTS | 2016年 / 8卷 / 03期
基金：
中国国家自然科学基金;
关键词：
spice; fruit; vegetable; liver cancer; anticancer; HUMAN HEPATOCELLULAR-CARCINOMA; N-ACETYLCYSTEINE CONJUGATE; PHOSPHATASE 2A ACTIVATION; HIPPOPHAE-RHAMNOIDES L; HUMAN HEPATOMA-CELLS; HEP 3B CELLS; IN-VITRO; ANTITUMOR-ACTIVITY; INDUCED APOPTOSIS; INDUCED HEPATOCARCINOGENESIS;
D O I：
10.3390/nu8030156
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Liver cancer is the most common malignancy of the digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment of liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, and some edible macro-fungi. These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs. This review summarizes the potential prevention and treatment activities of dietary natural products and their major bioactive constituents on liver cancer, and discusses possible mechanisms of action.
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页数：23
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