Silica sulfuric acid/ethylene glycol as an efficient catalyst for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrile derivatives

被引：14
作者：
Basyouni, Wahid M. [1 ]
Abbas, Samir Y. [1 ]
Abdelazeem, Nagwa M. [1 ]
El-Bayouki, Khairy A. M. [1 ]
El-Kady, Mohamed Y. [2 ]
机构：
[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
[2] Ain Shams Univ, Fac Sci, Chem Dept, Cairo, Egypt
来源：
SYNTHETIC COMMUNICATIONS | 2019年 / 49卷 / 22期
关键词：
2-Aminobenzimidazole; benzo[4; 5]imidazo[1; 2-a]pyrimidine; nitrile compounds; silica sulfuric acid; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; ACID; ALCOHOLS; ANTITUMOR; MILD;
D O I：
10.1080/00397911.2019.1652322
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient eco-friendly method was developed for the synthesis of new benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrile derivatives in excellent yields. The synthesis was achieved through the reaction of 2-aminobenzimidazole, aldehydes and active nitriles (malononitrle or ethyl cyanoacetae) in the presence of silica sulfuric acid/ethylene glycol. This protocol offers very short reaction times (in some cases, reaction times were reduced to five minutes), high yields and low cost. This method thus provides an improvement over the existing methods.
引用
收藏
页码：3112 / 3120
页数：9
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