Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents

被引：304

作者：

Kontogiorgis, C ^{[1
]}

Hadjipavlou-Litina, D ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2003年 / 18卷 / 01期

关键词：

carrageenin paw oedema; anti-inflammatories; antioxidants; arthritis; coumarins;

D O I：

10.1080/1475636031000069291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several linear and angular coumarins designed and synthesised as possible anti-inflammatory and antioxidant agents were evaluated for their biological activities, using the carrageenin-induced rat paw oedema model. In general, the compounds were found to be potent anti-inflammatory agents. Compound (4) was found to possess protective properties in adjuvant-induced arthritis in rats. The compounds were found to interact with 1,1-diphenyl-2-picryl-hydrazyl stable free radical (DPPH) whereas most of them were essentially inactive in other tests. The anti-inflammatory activity seemed to be connected with their reducing activity. R-M values were determined as an expression of their lipophilicity which was also calculated as clog P. Only a poor relationship existed between lipophilicity and anti-inflammatory activity.

引用

页码：63 / 69

页数：7

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