Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

被引：100

作者：

Bell, Richard L. ^{[1
,2
]}

Lopez, Marcelo F. ^{[3
]}

Cui, Changhai ^{[4
]}

Egli, Mark ^{[4
]}

Johnson, Kirk W. ^{[5
]}

Franklin, Kelle M. ^{[1
,2
]}

Becker, Howard C. ^{[3
]}

机构：

[1] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Inst Psychiat Res, Indianapolis, IN 46202 USA

[3] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston Alcohol Res Ctr, Charleston, SC 29425 USA

[4] NIAAA, Div Neurosci & Behav, NIH, DHHS, Bethesda, MD 20892 USA

[5] MediciNova Inc, San Diego, CA USA

来源：

ADDICTION BIOLOGY | 2015年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Alcohol; alcohol dependence; alcoholism; alcohol preference; AV-411; ethanol; ibudilast; MN-166; neuroimmune; phosphodiesterase; MIGRATION INHIBITORY FACTOR; ETHANOL EXPOSURE; BRAIN; MICE; MEDICATIONS; CONSUMPTION; ACTIVATION; DISEASE; SAFETY; RAT;

D O I：

10.1111/adb.12106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.

引用

页码：38 / 42

页数：5

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