Metal-Free Tandem Oxidative Cyclization for the Synthesis of 1,2-Dihydropyridazines and Pyrazoles

被引：15

作者：

Cheng, Dongping ^{[1
]}

Shen, Yinqiang ^{[1
]}

Wu, Ziliang ^{[1
]}

Xu, Xiaoliang ^{[2
]}

Yan, Jizhong ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 13期

关键词：

SYNERGISTIC CATALYSIS; ALLYLIC ALCOHOLS; DERIVATIVES; ALKENES; DIAMINATION; GENERATION; STRATEGY;

D O I：

10.1021/acs.joc.1c00020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), a novel oxidative coupling of hydrazones and 1,3-diarylpropenes has been disclosed to generate appealing beta,gamma-unsaturated hydrazones, which further undergo 5-exo-trig or 6-endo-trig cascade cyclization to give the respective 1,2-dihydropyridazines or pyrazoles selectively under metal-free conditions. The mechanisms of the coupling and subsequent cyclization are proposed.

引用

页码：8563 / 8575

页数：13

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