Immunology on chip: Promises and opportunities

被引：41

作者：

Baratchi, Sara ^{[1
,2
]}

Khoshmanesh, Khashayar ^{[1
]}

Sacristan, Catarina ^{[3
]}

Depoil, David ^{[3
]}

Wlodkowic, Donald ^{[4
]}

McIntyre, Peter ^{[2
]}

Mitchell, Arnan ^{[1
]}

机构：

[1] RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic, Australia

[2] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic, Australia

[3] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY USA

[4] RMIT Univ, Sch Appl Sci, BioMEMS Res Grp, Melbourne, Vic, Australia

来源：

BIOTECHNOLOGY ADVANCES | 2014年 / 32卷 / 02期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Microfluidics; Lab on a chip; Immunology; Immunoassays; CELL CHEMICAL LYSIS; WHOLE HUMAN BLOOD; ON-A-CHIP; MICROFLUIDIC DEVICE; CAPILLARY-ELECTROPHORESIS; GEL-ELECTROPHORESIS; MAMMALIAN-CELLS; CROSS-FLOW; T-CELLS; SEPARATION;

D O I：

10.1016/j.biotechadv.2013.11.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microfluidics has facilitated immunological studies by enhancing speed, efficiency and sensitivity of current analysis methods. It offers miniaturization of current laboratory equipment, and enables analysis of clinical samples without the need for sophisticated infrastructure. More importantly, microfluidics offers unique capabilities; including conducting multiple serial or parallel tasks as well as providing complex and precisely controlled environmental conditions that are not achievable using conventional laboratory equipment. Microfluidics is a promising technology for fundamental and applied immunological studies, allowing generation of high throughput, robust and portable platforms, opening a new area of automation in immunology. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：333 / 346

页数：14

共 123 条

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