Immunology on chip: Promises and opportunities

被引:41
作者
Baratchi, Sara [1 ,2 ]
Khoshmanesh, Khashayar [1 ]
Sacristan, Catarina [3 ]
Depoil, David [3 ]
Wlodkowic, Donald [4 ]
McIntyre, Peter [2 ]
Mitchell, Arnan [1 ]
机构
[1] RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic, Australia
[2] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic, Australia
[3] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY USA
[4] RMIT Univ, Sch Appl Sci, BioMEMS Res Grp, Melbourne, Vic, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
Microfluidics; Lab on a chip; Immunology; Immunoassays; CELL CHEMICAL LYSIS; WHOLE HUMAN BLOOD; ON-A-CHIP; MICROFLUIDIC DEVICE; CAPILLARY-ELECTROPHORESIS; GEL-ELECTROPHORESIS; MAMMALIAN-CELLS; CROSS-FLOW; T-CELLS; SEPARATION;
D O I
10.1016/j.biotechadv.2013.11.008
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Microfluidics has facilitated immunological studies by enhancing speed, efficiency and sensitivity of current analysis methods. It offers miniaturization of current laboratory equipment, and enables analysis of clinical samples without the need for sophisticated infrastructure. More importantly, microfluidics offers unique capabilities; including conducting multiple serial or parallel tasks as well as providing complex and precisely controlled environmental conditions that are not achievable using conventional laboratory equipment. Microfluidics is a promising technology for fundamental and applied immunological studies, allowing generation of high throughput, robust and portable platforms, opening a new area of automation in immunology. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:333 / 346
页数:14
相关论文
共 123 条
  • [1] Characterization of a membrane-based gradient generator for use in cell-signaling studies
    Abhyankar, VV
    Lokuta, MA
    Huttenlocher, A
    Beebe, DJ
    [J]. LAB ON A CHIP, 2006, 6 (03) : 389 - 393
  • [2] Directional decisions during neutrophil chemotaxis inside bifurcating channels
    Ambravaneswaran, Vijayakrishnan
    Wong, Ian Y.
    Aranyosi, Alexander J.
    Toner, Mehmet
    Irimia, Daniel
    [J]. INTEGRATIVE BIOLOGY, 2010, 2 (11-12) : 639 - 647
  • [3] A magnetic bead-based DNA extraction and purification microfluidic device
    Azimi, Sayyed Mohamad
    Nixon, Gavin
    Ahern, Jeremy
    Balachandran, Wamadewa
    [J]. MICROFLUIDICS AND NANOFLUIDICS, 2011, 11 (02) : 157 - 165
  • [4] Clever PCR: more genotyping, smaller volumes
    Baker, Monya
    [J]. NATURE METHODS, 2010, 7 (05) : 351 - 355
  • [5] Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity
    Baret, Jean-Christophe
    Miller, Oliver J.
    Taly, Valerie
    Ryckelynck, Michael
    El-Harrak, Abdeslam
    Frenz, Lucas
    Rick, Christian
    Samuels, Michael L.
    Hutchison, J. Brian
    Agresti, Jeremy J.
    Link, Darren R.
    Weitz, David A.
    Griffiths, Andrew D.
    [J]. LAB ON A CHIP, 2009, 9 (13) : 1850 - 1858
  • [6] ALLOGENEIC STIMULATION OF CYTO-TOXIC T-CELLS BY SUPPORTED PLANAR MEMBRANES
    BRIAN, AA
    MCCONNELL, HM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (19): : 6159 - 6163
  • [7] Nucleic acid purification using microfabricated silicon structures
    Cady, NC
    Stelick, S
    Batt, CA
    [J]. BIOSENSORS & BIOELECTRONICS, 2003, 19 (01) : 59 - 66
  • [8] High-sensitivity miniaturized immunoassays for tumor necrosis factor a using microfluidic systems
    Cesaro-Tadic, S
    Dernick, G
    Juncker, D
    Buurman, G
    Kropshofer, H
    Michel, B
    Fattinger, C
    Delamarche, E
    [J]. LAB ON A CHIP, 2004, 4 (06) : 563 - 569
  • [9] An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids
    Chen, Dafeng
    Mauk, Michael
    Qiu, Xianbo
    Liu, Changchun
    Kim, Jitae
    Ramprasad, Sudhir
    Ongagna, Serge
    Abrams, William R.
    Malamud, Daniel
    Corstjens, Paul L. A. M.
    Bau, Haim H.
    [J]. BIOMEDICAL MICRODEVICES, 2010, 12 (04) : 705 - 719
  • [10] Concentration and Purification of Human Immunodeficiency Virus Type 1 Virions by Microfluidic Separation of Superparamagnetic Nanoparticles
    Chen, Grace D.
    Alberts, Catharina J.
    Rodriguez, William
    Toner, Mehmet
    [J]. ANALYTICAL CHEMISTRY, 2010, 82 (02) : 723 - 728